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AM23-SN-11-L - AM23-SN-11-L: Challenging Antibody Investigations in the Immunohematology Reference Lab (Live)

‐ Oct 15, 2023 11:00am

Credits: None available.

Nearly all red cell antibody identification cases referred to IRLs are straightforward, being single, multiple, or autoantibodies. But in a small percentage, antibody identification is challenging, requiring the most experienced and educated minds and the best resources for various serologic and molecular techniques. This session will review a few specific case studies to demonstrate the resolution challenging antibody investigations and provide recommendations for the most appropriate blood for transfusion. Complex immunohematology cases may involve unknown high-prevalence antibodies, complex transfusion and transplant histories, and the presence of RHD and RHCE antigen variants.

Learning Objectives:

  • Illustrate the process for test selection to effectively solve complex immunohematology cases
  • Design detailed differentials for the choices of test approaches and resources
  • Integrate multiple test results into a comprehensive antibody interpretation and transfusion plan




  • Janis Hamilton, MS, MLS(ASCP)SBB:
    No financial relationships to disclose
  • Paul Mansfield, MLS(ASCP)SBB:
    No financial relationships to disclose
  • Thierry Peyrard, PharmD, PhD, EurSpLM:
    No financial relationships to disclose

All relevant financial relationships have been mitigated.


Credits: None available.