This session will focus on the role of anti-fibrinolytics and other hemostatic agents/adjuncts (such as prothrombin concentrates, rFVIIa, fibrinogen concentrates/cryoprecipitate) in controlling bleeding and lowering transfusion needs in pediatric trauma situations. Key animal experimental studies and pediatric/adult clinical studies that support its use in attenuating bleeding in pediatric patients will be presented. In addition, assays that can guide the use of hemostatic agents/adjuncts will be described.
Understand the difference in hemostasis between children and adults.
Describe the evidence for (or against) the use of tranexaminc acid in pediatric trauma and non-trauma bleeding situations.
Describe the evidence for (or against) the use of other hemostatic agents/adjuncts such as prothrombin concentrates (PCC) and other hemostatic agents (eg. rFVIIa, fibrinogen concentrates/cryoprecipitate) in pediatric trauma.
Describe assays that can guide use of these agents/adjuncts in bleeding pediatric patients.
Medical Director, Coagulation,